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KMID : 0377619640060010071
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Korean Jungang Medical Journal
1964 Volume.6 No. 1 p.71 ~ p.76
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Experimental and Clinical Trials of Astiban(Antimony Sodium Meso-2·3-Dimercaptosuccinate) in Clonorchiasis.
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朴炳宰/Park, Byung-Jae
金永麟/蘇鎭卓/李東奎/Kim, Young-Lin/Soh, Chin-Thack/Lee, Tong-Kyu
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Abstract
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Experimental and clinical trials of Astiban(Antimony sodium meso-2, 3-dimerc2iptosuccinate) upon the infection of Clonorchis sinensis are summarized as follows;
1. Egg reduction was observed in two rabbits after the administration of the drug (100 mg for three or five days).The adult worm showed moderate atrophic changes on vitelline glands.
2. Six of thirty one cases converted to complete egg negative, resulting 19. 4% of cure rate.
3. During the treatment, side effects were observed more or less in all cases and they were myoarthralgia, loss of appetite, nausea and vomiting, abdominal discomfort, diarrhea, abdominal pain, general weakness, and diziness, and ascites was experienced in one case.
4. Follow up studies to nine cases were carried on for three or six months, and found to show no reverse from the initial data.
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